Biography of Christopher Columbus, Italian Explorer

Biography of Christopher Columbus, Italian Explorer Christopher Columbus (c. October 31, 1451–May 20, 1506) was an Italian explorer who led voyages to the Caribbean, Central America, and South America. His exploration of these areas paved the way for European colonization. Since his death, Columbus has been criticized for his treatment of Native Americans in the New World. Fast Facts: Christopher Columbus Known For: Columbus completed four voyages to the New World on behalf of Spain, preparing the way for European colonization.Born: October 31, 1451 in GenoaDied: May 20, 1506  in Castile, Spain Early Life Christopher Columbus was born in Genoa (now Italy) in 1451 to Domenico Colombo, a middle-class wool weaver, and Susanna Fontanarossa. Though little is known about his childhood, it is assumed that he was well-educated because he was able to speak several languages as an adult and had considerable knowledge of classical literature. He is known to have studied the works of Ptolemy and Marinus, among others. Columbus first took to the sea when he was 14 years old, and he continued to sail throughout the rest of his youth. During the 1470s, he went on numerous trading trips that took him to the Aegean Sea, Northern Europe, and possibly Iceland. In 1479, he met his brother Bartolomeo, a mapmaker, in Lisbon. He later married Filipa Moniz Perestrello, and in 1480 his son Diego was born. The family stayed in Lisbon until 1485, when Columbus wife Filipa died. From there, Columbus and Diego moved to Spain, where Columbus began trying to obtain a grant to explore western trade routes. He believed that because the earth was a sphere, a ship could reach the Far East and set up trading routes in Asia by sailing west. For years, Columbus proposed his plans to the Portuguese and Spanish kings, but he was turned down each time. Finally, after the Moors were expelled from Spain in 1492, King Ferdinand and Queen Isabella reconsidered his requests. Columbus promised to bring back gold, spices, and silk from Asia, to spread Christianity, and to explore China. In return, he asked to be made admiral of the seas and governor of discovered lands. First Voyage After receiving significant funding from the Spanish monarchs, Columbus set sail on August 3, 1492, with three ships- the Pinta, Nina, and Santa Maria- and 104 men. After a short stop at the Canary Islands to resupply and make minor repairs, the ships set out across the Atlantic. This voyage took five weeks- longer than Columbus had expected, as he believed the world was much smaller than it is. During this time, many of the crew members became ill and some died from diseases, hunger, and thirst. Finally, at 2 a.m. on October 12, 1492, sailor Rodrigo de Triana sighted land in the area of what is now the Bahamas. When Columbus reached the land, he believed it was an Asian island and named it San Salvador. Because he did not find any riches here, Columbus decided to continue sailing in search of China. Instead, he ended up visiting Cuba and Hispaniola. On November 21, 1492, the Pinta and its crew left to explore on its own. On Christmas Day, the Santa Maria wrecked off the coast of Hispaniola. Because there was limited space on the lone Nina, Columbus had to leave about 40 men behind at a fort they named Navidad. Soon after, Columbus set sail for Spain, where he arrived on March 15, 1493, completing his first voyage west. Second Voyage After the success of finding this new land, Columbus set sail west again on September 23, 1493, with 17 ships and 1,200 men. The purpose of this second journey was to establish colonies in the name of Spain, check on the crew at Navidad, and continue the search for riches in what Columbus still thought was the Far East. On November 3, the crew members sighted land and found three more islands: Dominica, Guadeloupe, and Jamaica, which Columbus thought were islands off of Japan. Because there were still no riches to be found, the crew went on to Hispaniola, only to discover that the fort of Navidad had been destroyed and the crew killed after they mistreated the indigenous population. At the site of the fort, Columbus established the colony of Santo Domingo, and after a battle in 1495 he conquered the entire island of Hispaniola. He then set sail for Spain in March 1496 and arrived in Cadiz on July 31. Third Voyage Columbus’s third voyage began on May 30, 1498, and took a more southern route than the previous two. Still searching for China, Columbus found Trinidad and Tobago, Grenada, and Margarita on July 31. He also reached the mainland of South America. On August 31, he returned to Hispaniola and found the colony of Santo Domingo there in shambles. After a government representative was sent to investigate the problems in 1500, Columbus was arrested and sent back to Spain. He arrived in October and was able to successfully defend himself against the charges of treating both the locals and the Spaniards poorly. Fourth and Final Voyage Columbus final voyage began on May 9, 1502, and he arrived in Hispaniola in June. He was forbidden from entering the colony, so he continued to explore areas nearby. On July 4, he set sail again and later found Central America. In January 1503, he reached Panama and found a small amount of gold but was forced out of the area by those who lived there. After encountering numerous problems, Columbus set sail for Spain on November 7, 1504. After he arrived there, he settled with his son in Seville. Death After Queen Isabella died on November 26, 1504, Columbus tried to regain his governorship of Hispaniola. In 1505, the king allowed him to petition but did nothing. One year later, Columbus became ill, and he died on May 20, 1506. Legacy Because of his discoveries, Columbus is often venerated, notably in the Americas where places such as the District of Columbia bear his name and where many people celebrate Columbus Day. Despite this fame, however, Columbus was not the first to visit the Americas. Long before Columbus, various indigenous peoples had settled and explored different areas of the Americas. In addition, Norse explorers had already visited portions of North America. Leif Ericson is believed to have been the first European to visit the area and set up a settlement in the northern portion of Canadas Newfoundland some 500 years before the arrival of Columbus. Columbuss major contribution to geography is that he was the first to visit and settle in these new lands, effectively bringing a new area of the world to the forefront of the popular imagination. Sources Morison, Samuel Eliot.  The Great Explorers: the European Discovery of America. Oxford University Press, 1986.Phillips, William D., and Carla Rahn Phillips.  The Worlds of Christopher Columbus. Cambridge University Press, 2002.

Quotes Attributed to Epictetus

Quotes Attributed to Epictetus Epictetus (A.D. c. 55 - c.135) To a reasonable creature, that alone is insupportable which is unreasonable; but everything reasonable may be supported.Epictetus - Discourses Chap. ii. The rational and the irrational are naturally different for different persons as are good and evil and profitable and unprofitable. For this reason we need to learn how to adjust our conceptions of rational and irrational and keep them in harmony with nature. When we determine the rational and the irrational we use both our estimates of external things and the criterion of our own character. This makes it most important that we understand ourselves. You must know how highly you value yourself and at what price you will sell yourself; different men sell themselves at different prices.Epictetus - Discourses 1.2Courtesy of translator Giles Laurà ©n, author of The Stoics Bible. When Vespasian sent word to Helvidius Priscus not to attend the Senate, he answered: It is in your power to forbid me to be a member of the Senate, but so long as I am one I must attend its meetings.Epictetus - Discourses 1.2.Courtesy of translator Giles Laurà ©n, author of The Stoics Bible. If every man could be convinced heart and soul in the belief that we are all begotten by Zeus, father to both men and gods, I think he could no longer have any ignoble or mean thought about himself. If Caesar adopts you no one will be able to endure your conceit, but if you know you are a son of Zeus shouldnt you be elated? Two elements are commingled in us: the body which we have in common with the brutes and intelligence which we have in common with the gods. Many of us incline towards the former which is unblessed and mortal and only a few incline towards the latter which is divine and blessed. Clearly, every man is free to deal with things according to his opinions of them, and those few who think that their birth is a call to fidelity, self-respect and unerring judgement cherish no mean or ignoble thoughts about themselves, whereas the multitude do quite the opposite and cleave to their animal part and become rascally and degraded.Epictetus - Discourses 1.3.Courtesy of translat or Giles Laurà ©n, author of The Stoics Bible. He who is making progress has learned that desire is for things good and that aversion is for things evil, and further, that peace and calm are only achieved as a man gets the things he wants and avoids the things he doesnt want. Since virtue is rewarded with happiness, calm and serenity, progress towards virtue is progress towards its benefits and this progress is always a step towards perfection.Epictetus - Discourses 1.4.Courtesy of translator Giles Laurà ©n, author of The Stoics Bible. In a word, neither death, nor exile, nor pain, nor anything of this kind is the real cause of our doing or not doing any action, but our inward opinions and principles.Epictetus - Discourses Chap xi. Reason is not measured by size or height, but by principle.Epictetus - Discourses Chap. xii. O slavish man! will you not bear with your own brother, who has God for his Father, as being a son from the same stock, and of the same high descent? But if you chance to be placed in some superior station, w ill you presently set yourself up for a tyrant?Epictetus - Discourses Chap. xiii. When you have shut your doors, and darkened your room, remember never to say that you are alone, for you are not alone; but God is within, and your genius is within, and what need have they of light to see what you are doing?Epictetus - Discourses Chap. xiv. No great thing is created suddenly, any more than a bunch of grapes or a fig. If you tell me that you desire a fig, I answer you that there must be time. Let it first blossom, then bear fruit, then ripen.Epictetus - Discourses Chap. xv. Any one thing in the creation is sufficient to demonstrate a Providence to an humble and grateful mind.Epictetus - Discourses Chap. xvi. Were I a nightingale, I would act the part of a nightingale; were I a swan, the part of a swan.Epictetus - Discourses Chap. xvi. Since it is Reason which shapes and regulates all other things, it ought not itself to be left in disorder.Epictetus - Discourses Chap. xvii. If what the philosophers say be true,that all mens actions proceed from one source; that as they assent from a persuasion that a thing is so, and dissent from a persuasion that it is not, and suspend their judgment from a persuasion that it is uncertain, so likewise they seek a thing from a persuasion that it is for their advantage.Epictetus - Discourses Chap. xviii. Practise yourself, for heavens sake, in little things; and thence proceed to greater.Epictetus - Discourses Chap xviii. Every art and every faculty contemplates certain things as its principal objects.Epictetus - Discourses Chap. xx. Why, then, do you walk as if you had swallowed a ramrod?Epictetus - Discourses Chap. xxi. When one maintains his proper attitude in life, he does not long after externals. What would you have, O man?Epictetus - Discourses Chap. xxi. Difficulties are things that show what men are.Epictetus - Discourses Chap. xxiv. If we are not stupid or insincere when we say that the good or ill of man lies within his own will, and that all beside is nothing to us, why are we still troubled?Epictetus - Discourses Chap. xxv. In theory there is nothing to hinder our following what we are taught; but in life there are many things to draw us aside.Epictetus - Discourses Chap. xxvi. Appearances to the mind are of four kinds. Things either are what they appear to be; or they neither are, nor appear to be; or they are, and do not appear to be; or they are not, and yet appear to be. Rightly to aim in all these cases is the wise mans task.Epictetus - Discourses. Chap. xxvii. Everything has two handles, one by which it may be borne; another by which it cannot.Epictetus - Enchiridion. xliii. When a man prides himself on being able to understand and interpret a difficult book, say to yourself: If the book had been well written this man would have nothing on which to pride himself.Epictetus - Encheiridon 49.Courtesy of translator Giles Laurà ©n, author of The Stoics Bible. My object is to understand and follow Nature, so I look for someone who understands her and I read his book. When I have found a man of understanding, it is not for me to praise his book but rather to act on his precepts.Epictetus - Encheiridon 49.Courtesy of translator Giles Laurà ©n, author of The Stoics Bible. Once you have fixed on you governing principles, you must hold them as laws that you cannot transgress. Pay no heed to what is said of you for it is beyond your control.Epictetus - Encheiridon 50.Courtesy of translator Giles Laurà ©n, author of The Stoics Bible. The appearanc e of things to the mind is the standard of every action to man.Epictetus - That we ought not to be angry with Mankind. Chap. xxviii. The essence of good and evil is a certain disposition of the will.Epictetus - Of Courage. Chap. xxix. It is not reasonings that are wanted now; for there are books stuffed full of stoical reasonings.Epictetus - Of Courage. Chap. xxix. For what constitutes a child? Ignorance. What constitutes a child? Want of instruction; for they are our equals so far as their degree of knowledge permits.Epictetus - That Courage is not inconsistent with Caution. Book ii. Chap. i. Appear to know only this, never to fail nor fall.Epictetus - That Courage is not inconsistent with Caution. Book ii. Chap. i. The materials of action are variable, but the use we make of them should be constant.Epictetus - How Nobleness of Mind may be consistent with Prudence. Chap. v. Shall I show you the muscular training of a philosopher? What muscles are those? A will undisappointed; evils avoided; powers daily exercised; careful resolutions; unerring decisions.Epictetus - Wherein consists the Essence of Good. Chap. viii. Dare to look up to God and say, Make use of me for the future as Thou wilt. I am of the same mind; I am one with Thee. I refuse nothing which seems good to Thee. Lead me whither Thou wilt. Clothe me in whatever dress Thou wilt.Epictetus - That we do not study to make Use of the established Principles concerning Good and Evil. Chap. xvi. What is the first business of one who studies philosophy? To part with self-conceit. For it is impossible for any one to begin to learn what he thinks that he already knows.Epictetus - How to apply general Principles to particular Cases. Chap. xvii. Every habit and faculty is preserved and increased by correspondent actions,as the habit of walking, by walking; of running, by running.Epictetus - How the Semblances of Things Are to Be Combated. Chap. xviii. Whatever you would make habitual, practise it; and if you would not make a thing habitual, do not practise it, but habituate yourself to something else.Epictetus - How the Semblances of Things Are t o Be Combated. Chap. xviii. Reckon the days in which you have not been angry. I used to be angry every day; now every other day; then every third and fourth day; and if you miss it so long as thirty days, offer a sacrifice of thanksgiving to God.Epictetus - How the Semblances of Things Are to Be Combated. Chap. xviii. What saith Antisthenes? Hast thou never heard? It is a kingly thing, O Cyrus, to do well and to be evil spoken of.Epictetus - Golden Sayings - VII Whereas if Caesar were to adopt you, your haughty looks would be intolerable; will you not be elated at knowing that you are the son of God?Epictetus - Golden Sayings - IX There is petrifaction of the understanding; and also of the sense of shame. This happens when a man obstinately refuses to acknowledge plain truths, and persists in maintaining what is self-contradictory.Epictetus - Golden Sayings - XXIII If what philosophers say of the kinship of God and Man be true, what remains for men to do but as Socrates did; never, when asked ones country, to answer, I am an Athenian or a Corinthian, but I am a citizen of the world.Epictetus - Golden Sayings - XV But there is a great difference between other mens occupations and ours. . . . A glance at theirs will make it clear to you. All day long they do nothing but calculate, contrive, consult how to wring their profit out of food-stuffs, farm-plots and the like. . . . Whereas, I entreat you to learn what the administration of the World is, and what place a Being endowed with reason holds therein: to consider what you are yourself, and wherein your Good and Evil consists.Epictetus - Golden Sayings - XXIV True instruction is this: to learn to wish that each thing should come to pass as it does. And how does it come to pass? As the Disposer has disposed it. Now He has disposed that there should be summer and winter, and plenty and dearth, and vice and virtue, and all such opposites, for the harmony of the whole.Epictetus - Golden Sayings - XXVI Concerning the Gods, there are who deny the very existence of the Godhead; others say that it exists, but neither bestirs nor concerns itself nor ha s forethought for anything. A third party attribute to it existence and forethought, but only for great and heavenly matters, not for anything that is on earth. A fourth party admit things on earth as well as in heaven, but only in general, and not with respect to each individual. A fifth, of whom were Ulysses and Socrates are those that cry: I move not without Thy knowledge!Epictetus - Golden Sayings - XXVIII You must know that it is no easy thing for a principle to become a mans own, unless each day he maintain it and hear it maintained, as well as work it out in life.Epictetus - Golden Sayings - XXX What you shun enduring yourself, attempt not to impose on others. You shun slavery beware of enslaving others! If you can endure to do that, one would thing you had been once upon a time a slave yourself. For Vice has nothing in common with virtue, nor Freedom with slavery.Epictetus - Golden Sayings - XLI Above all, remember that the door stands open. Be not more fearful than children; but as they, when they weary of the game, cry, I will play no more, even so, when thou art in the like case, cry, I will play no more and depart. But if thou stayest, make no lamentation.Epictetus - Golden Sayings - XLIV Death has no terror; only a Death of shame!Epictetus - Golden Sayings - LV That was a good reply which Diogenes made to a man who asked him for letters of recommendation. That you are a man , he will know when he sees you; whether a good or bad one, he will know if he has any skill in discerning the good or bad. But if he has none, he will never know, though I write him a thousand times.Epictetus - Golden Sayings - LVII God is beneficent. But the Good also is beneficent. It should seem then that where the real nature of God is, there too is to be found the real nature of the Good. What then is the real nature of God?Intelligence, Knowledge, Right Reason. Here then without more ado seek the real nature of the Good. For surely thou dost not seek it in a plant or in an animal that reasoneth not.Epictetus - Golden Sayings - LIX Why, wert thou a statue of Phidias, an Athena or a Zeus, thou wouldst bethink thee both of thyself and thine artificer; and hadst thou any sense, thou wouldst strive to do no dishonour to thyself or him that fashioned thee, nor appear to beholders in unbefitting guise. But now, because God is thy Maker, is that why thou carest not of what sort thou shalt show thyself to be?Epictetus - Golden Sayings - LXI Since then every one must deal with each thing according to the view which he forms about it, those few who hold that they are born for fidelity, modesty, and unerring sureness in dealing with the things of sense, never conceive aught base or ignoble of themselves: but the multitude the contrary.Epictetus - Golden Sayings - IX You also must show the unlearned man the truth, and you will see that he will follow. But so long as you do not show it him, you should not mock, but rather feel your own incapacity.Epictetus - Golden Sayings - LXIII It was the first and most striking characteristic of Socrates never to become heated in discourse, never to utter an injurious or insulting word on the contrary, he persistently bore insult from others and thus put an end to the fray.Epictetus - Golden Sayings - LXIV When we are invited to a banquet, we take what is set before us; and were one to call upon his host to set fish upon the table or sweet things, he would be deemed absurd. Yet in a word, we ask the Gods for what they do not give; and that, although they have given us so many things!Epictetus - Golden Sayings - XXXV Knowest thou what a speck thou art in comparison with the Universe? That is, with respect to the body; since with respect to Reason, thou art not inferior to the Gods, nor less than they. For th e greatness of Reason is not measured by length or height, but by the resolves of the mind. Place then thy happiness in that wherein thou art equal to the Gods.Epictetus - Golden Sayings - XXIII Who would Hercules have been had he loitered at home? no Hercules, but Eurystheus. And in his wanderings through the world how many friends and comrades did he find? but nothing dearer to him than God. Wherefore he was believed to be Gods son, as indeed he was. So then in obedience to Him, he went about delivering the earth from injustice and lawlessness.Epictetus - Golden Sayings - LXXI The reason why I lost my lamp was that the thief was superior to me in vigilance. He paid however this price for the lamp, that in exchange for it he consented to become a thief: in exchange for it, to become faithless.Epictetus - Golden Sayings - XII No labour, according to Diogenes, is good but that which aims at producing courage and strength of soul rather than of body.Epictetus - Golden Sayings - LXII But thou art not Hercules, thou sayest, and canst not deliver others from their iniquitynot even Theseus, to deliver the soil of Attica from its monsters? Purge away thine own, cast forth thencefr om thine own mind, not robbers and monsters, but Fear, Desire, Envy, Malignity, Avarice, Effeminacy, Intemperance.Epictetus - Golden Sayings - LXXI If a man would pursue Philosophy, his first task is to throw away conceit. For it is impossible for a man to begin to learn what he has a conceit that he already knows.Epictetus - Golden Sayings - LXXII The question at stake, said Epictetus, is no common one; it is this: Are we in our senses, or are we not?Epictetus - Golden Sayings - LXXIV One who has had fever, even when it has left him, is not in the same condition of health as before, unless indeed his cure is complete. Something of the same sort is true also of diseases of the mind. Behind, there remains a legacy of traces and blisters: and unless these are effectually erased, subsequent blows on the same spot will produce no longer mere blisters, but sores. If you do not wish to be prone to anger, do not feed the habit; give it nothing which may tend its increase.Epictetus - Golden Sayings - LXXV No man can rob us of our Willno man can lord it over that!Epictetus - Golden Sayings - LXXXIII Wouldst thou have men speak good of thee? speak good of them. And when thou hast learned to speak good of them, try to do good unto them, and thus thou wilt reap in return their speaking good of thee.Epictetus - Golden Sayings - L The beginning of philosophy is to know the condition of ones own mind. If a man recognises that this is in a weakly state, he will not then want to apply it to questions of the greatest moment. As it is, men who are not fit to swallow even a morsel, buy whole treatises and try to devour them. Accordingly they either vomit them up again, or suffer from indigestion, whence come gripings, fluxions, and fevers. Whereas they should have stopped to consider their capacity.Epictetus - Golden Sayings - XLVI In theory it is easy to convince an ignorant person: in actual life, men not only object to offer themselves to be convinced, but hate the man who has convinced them. Whereas Socrates used to say that we should never lead a life not subjected to examination.Epictetus - Golden Sayings - XLVII

Auditing Essay Example | Topics and Well Written Essays - 1500 words - 7

Auditing - Essay Example 2). Inventories should always be stated at the lower cost and the market prices or the net realizable value. The net realizable value is the amount that the asset can fetch as at the reporting date, less the estimated costs required to complete the transaction. These could include selling costs and overhead costs. The values stated in the inventories of Abbey Plc. in the annual report for the year 2014 should be tested adequately to ensure that they are the correct market values of such inventories. Fixed assets are critical items, which the auditor should ascertain and ensure that values attached to them are their correct fair values to be disclosed to the shareholders (Rittenberg et al. 2011, p. 626). Disclosing the values of the fixed assets in excess of their correct fair values would make the financial statements to be overstated; thus provide shareholders with a wrong financial position of their company. Trade and other receivables should be recognized and carried at the lower cost of their original invoiced value and the recoverable amount. In case the time value of money is material, receivables should be carried at the amortized cost. The company should make provisions in situations where there is some adequate evidence that the amount would not be recovered in full. The balances should be written off when the chances of recovery are assessed as being remote (Henning et al. 2007, p. 313). Adequate audit procedures should be done to ensure that the company did not make too much or too little provision to cater for trade and other receivables, which could not be recovered. Also, before writing off bad debts, all the relevant procedures should be followed since some managers may decide to write off debts, which could not be written off with the objective of hiding the correct amount of revenue collected by the company

Genetic of Hereditary angioedema Research Paper

Genetic of Hereditary angioedema - Research Paper Example Mutation can result from alteration or modification in the nucleotide sequence. In line with this, Type-III individuals involve mutation in F12 gene which codes for coagulation factor XII (Hageman factor). Since Type-III is estrogen dependent, this type of HAE occurs only among the female population. Up to date, only Faiyaz-Ul-Haque et al. (2010) conducted a study with regard to HAE among the Middle Eastern Arab patients. HAE is a rare kind of hereditary disorder (Kesim et al., 2011). Therefore, healthcare professionals should study the genetic etiology of this disease by determining its genetic components that have occurred in different geographical region across the world. To assist the healthcare professionals in their study of HAE in UAE, a literature review will be conducted to identify the genetic etiology of HAE. Literature Review HAE can result from the functional deficiency of the C1 esterase inhibitor (C1INH) protein (Gosswein et al., 2008; Papadopoulou-Alataki et al., 2008 ). Basically, C1INH is an inhibitor that activates the proteases C1r and C1s. C1INH is also responsible for activating the coagulation Factor XII (responsible for checking the formation of bradykinin) and the plasma kallikrein (Duan et al. 2009; Bell et al., 2008; Gosswein et al., 2008). Pappalardo et al. (2008) explained that deficiency of C1INH is actually caused by the mutations in its structural gene. Using a genetic screening method for C1INH gene (SERPIN1G) in Italy, Pappalardo et al. (2008) found out that the presence of amino acid residues, which are important in protein function, could trigger mutations in the C1INH gene. Also related to the functional deficiency of C1INH, Papadopoulou-Alataki et al. (2008) revealed that â€Å"a new missense mutation in exon 2 of the C1INH gene, c.1A>G; p.Met-22Val (p.Met1Val)†, is common among patients with HAE. A study carried out in Greece by Speletas et al. (2009), with 11 HAE cases from 3 unrelated families, displayed diminished C1 inhibitor antigen levels when analysis was performed for SERPING1 mutations. The findings recognized conversion of TC to AA as the main cause of alteration. This toggle can turn the codon as a stop signal to terminate the polypeptide. However, the second family exhibited W482X mutation, while the third family displayed missense mutation M1V, signifying diversity in mutation in the area. Genetic mutation analysis in similar manner was performed in a Turkish family by Bork et al (2011), suggesting that HAE individuals with normal C1-inhibitor possess two missense mutations in codon of coagulation factor 12 gene in a few families, while in others, deletion of 72 base pairs (bp) was recognized. The study instituted deletion of 48 base pairs of exon 9, (otherwise responsible for coding amino acids 324 to 340), together with 24bp deletion of intron 9. Deletion of 72 bp was situated in the same F12 gene region as the missense mutations p.Thr328Lys* and p.Thr328Arg* accounted earlier, s ignifying a close linkage between F12 gene mutations altering the FXII proline. The mutation in the region was associated with proline rich sequence of FXII protein and HAE cases with normal C1-ING (Bork et al., 2011). Duan et al. (2009) also performed genetic analysis of FXII and bradykinin catabolic enzymes in Type-III

Problem of Brain Drain Essay Example for Free

Problem of Brain Drain Essay Good Morning maam, and Hello to my friends. let me tell about my topic, its the problem of brain drain. The stupidity by Albert Einstein can be related with my topic. Before starting, my friends, i want to know, how many of you want to go to US, Canada, UK, France, or any other developed country. And how many of you have made up mind to stay there if you could? Thats good you are aware about Human Capital Flight and most of you want to stay here and serve your country. But or, This was a obvious result. i can you tell why? This phenomenon is what called brain drain or human capital flight. Like you,  Every year 250,000 youth are reported to leave the country for various reasons. And of them around fifty per cent of the 1,000 that graduate in medicine in Nepal each year leave to work abroad – permanently. They seek opportunities in its various manifestation — higher living standards, employment, better income, education, a luring western lifestyle, stability and security. Like you said. The list shows everything our country is incapable of providing to the youth. Hence, it is not surprising, if i say, that 556 youth leave the country to go across the seas in a given day. How many of them return to their homeland? The inflow number is almost negligible. This is where the use of word brain drain comes. â€Å"Brain drain† as defined by Britannica is departure of educated or professional people from one country, usually for better pay or living conditions†. Because if it, Nepal is losing a significant proportion of its intellectuals. Also, that the country loses workers and the money it put into training them in college, and the money often put for the health and safety of citizen. Majority has migrated to USA, UK or Australia. Also, the skilled working youth have left for Gulf countries to do labour work. Qualified farmers have been vanished to the third world. Than what to do? Before that, i want to inform you that, developed country who are getting these people are benefited because of brain gain. Why US had land on mars? Here are some reason related to this topic: it has the world’s most intelligent and creative minds collected from every corner. because best universities of the world are there in US due to which people go there for study and quality, and settle there. moreover the universities gives scholarship to attract the sharp and intellectual minds by which we all are easily attracted. Talents play important roles in helping a country develop. Different areas and nations have distinct policies to retain skilled workers due to the different national or regional situation. in African countries, the health systems have been severely affected by brain drain, so various measures have been suggested and tried to limit the migration of health workers to rich countries. In Kuwait, people have argued the country should cultivate a sense of security and hope among the elite to curb brain drain because people are not so confident of their countries future. China tries to create a normal and free atmosphere and mechanism that would help talents flourish. And in India, although suffering severe brain drain every year, the Indian government has not to adopted strict policies because they believe that the overseas talent will eventually contribute to the nation in the future. so lets all of us stay in our own motherland to serve here and make gold from it. i am sure i am staying in Nepal and help develop, grow and prosper my country.

The UK Advertising Industry :: Adverts, Marketing

Advertising is used to persuade us to do something. Whether it is to purchase a product, or to donate our money to a charity. Advertising is to persuade you to give something, to take on a message – not just to buy something. Advertising is not just pictures, words and slogans, but font’s and colors are essential when advertising. There are many different forms of advertising. Some of these include: †¢ Television †¢ Magazine †¢ Radio †¢ Junk mail †¢ Direct †¢ Text messaging †¢ Billboards †¢ Banners and flyers †¢ Bus shelters †¢ Pop-ups †¢ Internet Sites †¢ Cinema There are loads! But the main forms of advertising are generally – Television, Radio and Print based, we see them everyday and everywhere. Advertising is used to attract their target audience to advertise their products, and if successful, to purchase their product. Advertisers use certain techniques in order to make us feel as if we have longed all of our lives for this, and they are very clever at doing so. It is thought that approximately  £98 million is spent every year on advertising. 50% of money that is spent on advertising is spent on the press newspapers, magazines and trade papers. 27% is spent on television advertising, 11% is spent on direct advertising, and 7% is spent on Radio advertising, approximately 5% for Billboards and Bus shelter advertising and 0.5% for Cinema advertising. Personally, I feel that Print – based advertising is the most popular form of advertising as is long – lived. By that I mean that unlike television advertising, it does not appear for a certain amount of time, then disappeared and then quite often forgotten about. Another issue is that with television advertising you may not be watching when

Measuring Return on Investment (ROI)

Before starting to compare and measure the return of investment for an information system, it is better to define terms such as Information Technology and Return of Investment or ROI. Information technology is a field concerned with the production, manipulation, sharing and transfer or information through the use of electronically-based equipments to satisfy man’s needs (Albacea p. 4).Thus, in this definition we are not just referring to information itself but also for the communication aspects of the information system which is of wide use today. The Return of Investment, on the other hand, includes the costs and benefits in putting up a firm. Mainly, it is more focused on maximizing the benefits of the firm. In dealing with information systems, the definition of the return of investment is better to be extended so a to include not only the tangible but also the tangible benefits a firm or an office can derived in establishing their own information system (Grimes).To make a c lear measurement of the ROI, let us have only two groups of consideration. Since most of the websites on the internet are focused only on either commercial or information sake, then we shall consider the firms that invests on utilizing information systems for commercial purposes and the other ones are those that utilizes the information system for information sake such as the government.In the first category, measuring the cost of building an information-related investment such as websites for selling or doing e-commerce can be clearly seen. E-commerce is an innovation in the information technology where consumers can transact with sellers using only information system (Albacea p. 256). Since the cost for hiring a programmer, for example, in creating a website for a commercial firm, the hardware and other features such as searching or blog which can be brought through licensing are known, then the total cost of establishing this set up can be computed and is just can be known by mak ing a total of all of the expenses and efforts.The other part, which is computing the benefits, is rather the difficult part of it. This may be the reason why business owners and IT leaders are not interested in knowing or having a precise or definite benefit evaluation or effectiveness after they had made a website or an e-commerce page. According to Mary K. Pratt of the Computerworld of US in one of her features, the ROI for a website must be necessarily measured.She justified the ROI is truly measurable, and that those companies that are not measuring it doesn’t really concern of what their money’s worth. She takes, for example, Kia Motors. Kia Motors has for their websites visitor and mostly, what their basis of ranking is on the probability or likelihood of the customer to purchase a motor. They said that those that are downloading their white page are more likely to purchase a motor than those that only browse through their homepage.They can also measure the bene fits on how advertisements on the Internet have changed their production and gross profit. If they see that they had made an advertisement on the Internet but has no increase on the sales, assuming all other factors are held constant, then the information-based technique they use is ineffective.Since ROI’s concern is in costs and benefits, we should also take the advantages of having information related systems than not having any. For example, we can measure how we can save money by replacing the paper ads or printed documents by the electronic version.About 18%, according to the analysts, of the printed document of a business firm becomes expired or not updated after just seven days or a week-long of time. Thus, after this period, they must be replaced by the updated ones. On the other hand, updating publications on the web will cost less than updating the printed ones (McGrath). Hence, this is one way of showing how information systems can cause a movement of the computati on of the ROI.For the firms that utilizes the information system for commercial purposes, ROI can be measured in this way – the cost or the expenses can be easily calculated by just summing up the expenses made in putting up or establishing an electronic-based project, and the benefits, though not clearly seen, can be calculated by taking into consideration its effect on the business and how it can cut costs for the establishment.Now, let us look at the second category which is the firms or offices that utilizes information system for information-sake. The most common example for this category is the government. Usually, included in their budget is the allocation for having information systems that are helpful for public. If the benefits in the commercial-related are not clearly seen, here in the second category, the benefits are even more difficult to measure.Take United States for example. According to Center for Technology of Government at the University of Albany, even af ter some years of having information system exclusive for government information, the return of investment for this particular project is uncertain and is very hard to put in numbers (ctg.albany.edu†¦PrintVersion=1). Why is this so?Similar to the first category, the input resources for putting up or for the establishment of the information system to be used by the government can be readily computed for this is only the sum of all the expenses needed in the establishment. This will surely includes the wages or salaries of the personnel involved, the purchases made, and other licensing expenses.Government usually has its websites for its departments to ensure that the public will be well informed of national issues and information that are of public concern or the public can have great use of them. Again, return of investment is concern with the cost and the benefits. Now, how can we measure the benefits? If the members of the first categories’ benefits can be measured by seeing the effect of the system to their business, government’s measurement of the benefits is a lot more different.Remember that the benefits as defined earlier simultaneously with the Return of Investment don’t only include the tangible benefits but also the non-tangible ones. Thus, looking at the example earlier, the government has its own way of measuring the benefits. They had a standard assessment technique that gives results whether their investments or efforts in putting up the information system dedicated to serve the public has a significant effect or just a waste of time, effort and money (Grimes).This assessment technique needs some adjustments as justified by the Center of Technology for Government. This leads them to propose the Public Value Framework (Cresswell). The Public Value Framework emphasizes the role and importance of the public in assessing the performance of the information system used by the government. Unlike the previous system where only t he government are responsible for the evaluation done, the second system or the Public Value Framework will give power for the public in assessments.Therefore, for the firms or offices that utilize information system for information sake, like the first one, they had a clear computation for cost but a rather difficult computation for benefits. The ROI can be computed by computing the cost through obtaining the summation of all the expenses and the benefits can be seen on the effects or how their objectives of putting up the system are fulfilled. That is, if the public has more satisfaction in using the system established by the government, then the government’s return of investment is indeed higher.In general, measuring the return of investment for an information system is not an easy task because of the complexity on the non-tangible benefits it has to offer, even if the cost of establishing the information system is clearly and be easily computed. In the end, the basis of t he measurement of the return of investment is still in how it would affect the entities it is intended to be useful for or how the goals or objectives of a firm who puts up the system is attained or become more possible. It is recommended that more studies be made to make a standard basis for computation of the return of investment even if it has to involve many factors that are hard to put in numbers.ReferencesPratt, Mary K.( May 28, 2007) â€Å"Measuring Your Website’s Return of Investment.† Business Technology Leadership. 6 July 2007. .Cresswell, Anthony M, et al. (September 2006). Advancing Return of Investment Analysis for Government IT. 6 July 2007Grimes, Brad and Joab Jackson. (September 2006). What’s you IT investment worth –really? 6 July 2007Center for Technology in Government. 6 July 2007McGrath, George   and Anthony Schneider. Measuring Intranet Return On Investment. 6 July 2007.Albacea, Eliezer A. Information Technology Literacy I. UPLB, Ph ilippines: UPLB Foundation, Inc. 2005.

Analysis Vission and Mission of Coca-Cola Essay

In general, Coca-cola vision guides all members to understand what the company does, how it is done, and who it is done for also keeps the employees focused on the realistic goals of the firm, customers, investors, and other business partners. An effective vision should consists of two component which the first one is a cognitive component; which focuses on outcomes and how the best to achieve it, and the second component is affective component which will helps to motivate people and gain their commitment toward it( Boal and Hooijberg 2001). Base on Coca-cola vision statement show that they apply the affective component which increasing motivation and commitment among their employees, customers and business partners. The six P’s of Coca-cola vision which is People,, Portfolio, Partners, Planet, Profit and Productivity is the guideline to increase motivation and commitment. These six P’s also clearly mention the desirable future target for each component internally and externally of the firm, which is among people (employees), portfolio (product), partners (customers and suppliers), planet (moral obligation), profit and productivity. These visions also challenge all to participate and reach the organization goals. As a good vision, the internal (organizational beliefs and values) as well as external (shared understanding of the market environment) needs to be aligned. Besides, the Coca-cola vision statement also focuses on how the organizational members relate to the vision and shared each others. †¢People: Be a great place to work where people are inspired to be the best they can be. †¢Portfolio: Bring to the world a portfolio of quality beverage brands that anticipate and satisfy people’s desires and needs. †¢Partners: Nurture a winning network of customers and suppliers, together we create mutual, enduring value. †¢Planet: Be a responsible citizen that makes a difference by helping build and support sustainable communities. †¢Profit: Maximize long-term return to shareowners while being mindful of our overall responsibilities. †¢Productivity: Be a highly effective, lean and fast-moving organization This is a good sample of vision statement because it’s not too specific and realistic to achieve by all their members. This vision statement also encourages all members to participate in achieve the vision.

Conversation Topics for College Office Hours

Conversation Topics for College Office Hours Its no secret: college professors can be intimidating. After all, theyre super smart and in charge of your education- not to mention your grades. That being said, of course, college professors can also be really interesting, really engaging people. Your professors likely encourage you to come speak with them during office hours. And you may, in fact, have a question or two youd like to ask. If youd like a few additional topics to have on hand for your conversation, consider any of the following  things to talk to your professor about: Your Current Class If youre currently taking a class with a professor, you can easily talk about the class. What do you like about it? What do you find really interesting and engaging? What do the other students like about it? What recently happened in class that youd like more information on, that you found helpful, or that was just plain funny? An Upcoming Class If your professor is teaching a class next semester or next year that youre interested in, you can easily talk about it. You can ask about the reading load, what kinds of topics will be covered, what expectations the professor has for the class and for students taking the class, and even what the syllabus will look like. A Previous Class You Really Enjoyed Theres nothing wrong with talking to a professor about a previous class you took with him or her that you really enjoyed. You can talk about what specifically you found interesting and ask if your professor can suggest other classes or supplemental reading so that you can pursue your interests further. Graduate School Options If youre thinking about graduate school- even just a tiny bit- your professors can be great resources for you. They can talk to you about different programs of study, what youre interested in, what graduate schools would be a good match for your interests, and even what life as a graduate student is like. Employment Ideas It could be that you absolutely love botany but have no idea what you can do with a botany degree once you graduate. A professor can be a great person to talk to about your options (in addition to the career center, of course). Additionally, they may know of internships, job opportunities, or professional contacts that can help you along the way. Anything Covered in Class That You Loved If you recently went over a topic or theory in class that you absolutely loved, mention it to your professor! It will undoubtedly be rewarding for him or her to hear about, and you can find out more about a topic you didnt know youd love. Anything Youre Struggling With in Class Your professor can be a great- if not the best- resource for getting clarity or more information about something youre struggling with. Additionally, a one-on-one conversation with your professor can provide you with an opportunity to walk through an idea and ask questions in a way that you simply cannot do in a large lecture hall. Academic Difficulties If youre facing larger academic struggles, dont be too afraid to mention it to a professor you like. He or she might have some ideas to help you out, might be able to connect you with resources on campus (like tutors or an academic support center), or just might give you a great pep talk that helps your refocus and recharge. Personal Problems That Are Impacting Your Academics While professors arent counselors, its still important for you to let them know about any personal problems youre facing that might be having an effect on your academics. If someone in your family is very sick, for example, or if youre financially struggling because of an unexpected change in financial status, it might be helpful for your professor to know. Additionally, it can be wise to mention these kinds of situations to your professor when they first appear instead of when they become a problem. How Current Events Connect With the Course Material Many times, the material(s) covered in class are large theories and concepts that dont always seem like they connect to your day-to-day life. In reality, however, they often do. Feel free to talk with your professor about current events and how they might connect to what youre learning in class. A Letter of Recommendation If youre doing well in class and you think your professor likes and respects your work, consider  asking your professor for a letter of recommendation  if you need one. Letters of recommendation that have been written by professors can be especially helpful when youre applying for certain types of internships or even graduate school or research opportunities. Study Tips It can be all too easy to forget that professors were once undergraduate students, too. And just like you, they likely had to learn  how to study at the college level. If youre struggling with study skills, talk to your professor about what theyd recommend. This can be an especially helpful and important conversation to have before an important midterm or final, too. Resources on Campus That Can Help Academically Even if your professor wants to help you more, he or she might simply not have the time. Consider, then, asking your professor about other academic support resources that you can use, like a specific upper-class or graduate-level student whos a great tutor or a great TA who offers extra study sessions. Scholarship Opportunities Your professor undoubtedly receives regular mailings and emails about scholarship opportunities for students interested in certain academic fields. Consequently, checking in with your professors about any scholarship opportunities they know about might easily result in some helpful leads that you might otherwise not find out about. Jop Opportunities True, the career center and your own professional network can be your main sources of job leads. But professors can also be a great resource to tap into. Make an appointment with your professor to talk generally about your job hopes or options as well as what connections your professor might know about. You never know what former students they still keep in touch with, what organizations they volunteer with, or what other connections they may have to offer. Dont let your nervousness about talking with your professors disconnect you from what could be a great future job!

How to Analyze a Historical Document

How to Analyze a Historical Document It can be easy when examining a historical document that relates to an ancestor to look for the one right answer to our question - to rush to judgment based on the assertions presented in the document or text, or the conclusions we make from it. It is easy to look at the document through eyes clouded by personal bias and perceptions engendered by the time, place and circumstances in which we live. What we need to consider, however, is the bias present in the document itself. The reasons for which the record was created. The perceptions of the documents creator. When weighing the information contained in an individual document we must consider the extent to which the information reflects reality. Part of this analysis is weighing and correlating evidence obtained from multiple sources. Another important part is evaluating the provenance, purpose, motivation,  and constraints of the documents which contain that information within a particular historical context. Questions to consider for every record we touch: 1. What Type of Document Is It? Is it a census record, will, land deed, memoir, personal letter, etc.? How might the record type affect the content and believability of the document? 2. What Are the Physical Characteristics of the Document? Is it handwritten? Typed? A pre-printed form? Is it an original document or a court-recorded copy? Is there an official seal? Handwritten notations? Is the document in the original language in which it was produced? Is there anything unique about the document that stands out? Are the characteristics of the document consistent with its time and place? 3. Who Was the Author or Creator of the Document? Consider the author, creator and/or informant of the document and its contents. Was the document created first-hand by the author? If the documents creator was a court clerk, parish priest, family doctor, newspaper columnist, or other third party, who was the informant? What was the authors motive or purpose for creating the document? What was the author or informants knowledge of and proximity to the event(s) being recorded? Was he educated? Was the record created or signed under oath or attested to in court? Did the author/informant have reasons to be truthful or untruthful? Was the recorder a neutral party, or did the author have opinions or interests that might have influenced what was recorded? What perception might this author have brought to the document and description of events? No source is entirely immune to the influence of its creators predilections, and knowledge of the author/creator helps in determining the documents reliability. 4. For What Purpose Was the Record Created? Many sources were created to serve a purpose or for a particular audience. If a governmental record, what law or laws required the documents creation? If a more personal document such as a letter, memoir, will, or family history, for what audience was it written and why? Was the document meant to be public or private? Was the document open to public challenge? Documents created for legal or business reasons, particularly those open to public scrutiny such as those presented in court, are more likely to be accurate. 5. When Was the Record Created? When was this document produced? Is it contemporary to the events it describes? If it is a letter is it dated? If a bible page, do the events predate the bibles publication? If a photograph, does the name, date or other information written on the back appear contemporaneous to the photo? If undated, clues such as phrasing, form of address, and handwriting can help to identify the general era. First-hand accounts created at the time of the event are generally more reliable than those created months or years after the event occurred. 6. How Has the Document or Record Series Been Maintained? Where did you obtain/view the record? Has the document been carefully maintained and preserved by a government agency or archival repository? If a family item, how has it been passed down to the present day? If a manuscript collection or other item residing in a library or historical society, who was the donor? Is it an original or derivative copy? Could the document have been tampered with? 7. Were There Other Individuals Involved? If the document is a recorded copy, was the recorder an impartial party? An elected official? A salaried court clerk? A parish priest? What qualified the individuals who witnessed the document? Who posted the bond for a marriage? Who served as godparents for a baptism? Our understanding of the parties involved in an event, and the laws and customs which may have governed their participation, aids in our interpretation of the evidence contained within a document. In-depth analysis and interpretation of a historical document is an important step in the genealogical research process, allowing us to distinguish between fact, opinion, and assumption, and explore reliability and potential bias when weighing the evidence it contains. Knowledge of the historical context, customs,  and laws influencing the document can even add to the evidence we glean. The next time you hold a genealogical record, ask yourself if you have really explored everything the document has to say.

Obamas election to be the first black president of the USA Essay

Obamas election to be the first black president of the USA - Essay Example There are many opinions some of which the paper takes up relating to essentially two of the political theories. There are many opinions about the methodology of study of political science. Now the question is which study will be best suited to test the empirical or theoretical validity to justify Obama’s selection as the president of U.S. In this respect what study can give us a perfect prediction of Obama’s success in the last general election in U.S.A? Although there is no proven mathematical formula of politics for his success. There is also a debate as to what are the predicted factors that led him to be the president. Political theorists differ about the political prediction in the U.S in recent times over the issue. The paper carefully analyzes the question - Is there any calculative mathematical formulae used for Obama’s success to the chair of the president? The method followed is this paper is that of secondary research encompassing a literature review of four works out of which the works of Ian Shapiro (2002), ‘Problems, Methods and Theories in the Study of Politics’ and that of Peter Guy (2005), ‘Institutional theory in political science’ are the main ones from where two theories have been adopted for the analysis in this paper. Shapiro describes the political scenario of America as a fractured discipline. This theory relates to problem driven and theory driven study of politics. The paper finally focuses on the importance of predictability of the factors leading to a political event adopting the case of Obama’s election. In respect of the research question we can discuss two studies, namely, 1) â€Å"Problems, Methods and Theories in the Study of Politics† by Shapiro (2002): The theory states that the science of American politics is basically a fractured discipline; and 2) â€Å"Institutional theory in political science† by Guy (2005): The theory of institutionalism may be divided into two categories